Nisoxetine (hydrochloride)
CAS No. : 57754-86-6
| Size | Price | Stock |
|---|---|---|
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| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $560 | In-stock |
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| Cat. No. : | HY-B1704A |
| M.Wt: | 307.82 |
| Formula: | C17H22ClNO2 |
| Purity: | >98 % |
| Solubility: | H2O : 8.33 mg/mL (ultrasonic;warming;heat to 60°C);DMSO : 250 mg/mL (ultrasonic) |
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].
IC50 & Target:Kd: 0.76 nM (NET)[1]
In Vitro:Nisoxetine hydrochloride inhibits [3H]Nisoxetine binding to rat frontal cortical membranes with a Ki of 1.4±0.1 nM[2].
Nisoxetine hydrochloride inhibits [3H]Noradrenaline uptake into rat frontal cortical synaptosomes with a Ki of 2.1±0.3 nM[2].
Nisoxetine hydrochloride inhibits Na+ currents with IC50s of 1.6 and 28.6 µM at the membrane potential of -70 and -100 mV, respectively[3].
In Vivo:Nisoxetine (2.2 µM; a single intrathecal injection) hydrochloride shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively[3].
Nisoxetine (3,10, 30 mg/kg, i.p.) hydrochloride inhibits refeeding response (intake of standard chow) in rats[4].
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