Equisetin
CAS No. : 57749-43-6
| Size | Price | Stock |
|---|---|---|
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| 5mg | $640 | In-stock |
| 10mg | $980 | In-stock |
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| Cat. No. : | HY-N6711 |
| M.Wt: | 373.49 |
| Formula: | C22H31NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming) |
Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC50 = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects[1][2][3][4][5][6][7][8][9][10][11].
In Vitro:Equisetin (50-300 μM, 6 h) inhibit the production of virulence factor, biofilm formation, and swarming motility of Pseudomonas aeruginosa PAO1[4].
Equisetin shows cytotoxicity against human CCRF-CEM cells assessed as growth inhibition by SRB assay, with a GI50 of 144 nM[7].
Equisetin (1-6 μg/mL, 0-6 h) removes Staphylococcus aureus from IEC-6 cells by enhancing host autophagy and inducing mitochondria-mediated ROS generation[8].
Equisetin (20 μM, 7 days) inhibits adiposity through AMPK-dependent regulation of brown adipocyte (BA) differentiation[9].
Equisetin (0.01-100 μM, pre-stimulates 12 h) attenuates lipid droplet accumulation and foam cell formation in macrophages[10].
Equisetin (0.01-10 μM) inhibits LPS and oxLDL-induced inflammatory responses in macrophages (RAW264.7 and BMDM)[10].
Equisetin (4 µg/mL) can potentiate Colistin (HY-113678) activity against multi-drug resistant gram-negative bacteria including Colistin -resistant strains[11].
In Vivo:Equisetin (20-80 mg/kg, i.g., 6 weeks) inhibits obesity and increased energy expenditure in high-fat diet-induced obese mice through inhibition of the enzymatic activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)[5].
Equisetin (10 mg/kg, i.p., 6 h) shows significant anti-infective activity in a mouse model of Staphylococcus aureus ATCC 29213 infection[8].
Equisetin (5-20 mg/kg, p.o., every two days until 12 weeks) prevents atherosclerosis in mice by binding to and inhibiting the activity of STAT3[10].
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