1'-Hydroxy bufuralol
CAS No. : 57704-16-2
(Synonyms: Ro 03-7410)
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| Cat. No. : | HY-122277 |
| M.Wt: | 277.36 |
| Formula: | C16H23NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
1'-Hydroxy bufuralol is the main metabolite of Bufuralol (HY-105124) by the cytochrome P450 isoenzymes 2D1 and 2D2 (CYP2D1/2). 1'-Hydroxy bufuralol can be used to determine CYP2D1/2 enzyme activity[1][2]. In Vitro: Bufuralol is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.
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