2-Methylacetophenone

2-Methylacetophenone (O-Methylacetophenone), acetophenone derivative and acaricide, is a xanthine dehydrogenase (XDH) inhibitor. 2-Methylacetophenone competitively binds to the XDH active site, blocking the pathway for xanthine to be converted to uric acid. 2-Methylacetophenone can be used for the study of hyperuricemia and house dust^[1][2]. In Vitro:2-Methylacetophenone (0.64-1.25 μg/cm²; 24 h) exhibits potent acaricidal activity against D. farinae, with an LD₅₀ of 1.25 μg/cm² in vapor phase assays (8.00 times more toxic than benzyl benzoate) and an LD₅₀ of 0.64 μg/cm² in contact phase assays (11.75 times more toxic than benzyl benzoate)^[1].
2-Methylacetophenone (0.75-1.43 μg/cm²; 24 h) exhibits potent acaricidal activity against D. pteronyssinus, with an LD₅₀ of 1.43 μg/cm² in vapor phase assays (6.69 times more toxic than benzyl benzoate) and an LD₅₀ of 0.75 μg/cm² in contact phase assays (8.02 times more toxic than benzyl benzoate)^[1].
2-Methylacetophenone (1.45-2.68 μg/cm²; 24 h) exhibits potent acaricidal activity against T. putrescentiae, with an LD₅₀ of 2.68 μg/cm² in vapor phase assays (4.56 times more toxic than benzyl benzoate) and an LD₅₀ of 1.45 μg/cm² in contact phase assays (7.31 times more toxic than benzyl benzoate)^[1].