Fenobam
CAS No. : 57653-26-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $210 | In-stock |
| 25mg | $450 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-101478 |
| M.Wt: | 266.69 |
| Formula: | C11H11ClN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction[1][2][3]. In Vitro:Fenobam (300 μM; 72 h) significantly inhibits proliferation and induces apoptosis in LM7 cells[2]. In Vivo:Fenobam (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3].
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