Nitrosoglutathione
CAS No. : 57564-91-7
(Synonyms: GSNO; RVC-588; S-Nitroso-L-glutathione)
| Size | Price | Stock |
|---|---|---|
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| 10mg | $95 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $400 | In-stock |
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| Cat. No. : | HY-D0845 |
| M.Wt: | 336.32 |
| Formula: | C10H16N4O7S |
| Purity: | >98 % |
| Solubility: | H2O : 16.67 mg/mL (ultrasonic;warming;heat to 60°C) |
Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].
In Vitro: Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].
In Vivo: Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3].
Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, but
up-regulates endothelial NOS expression in the flap vessels[4].
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