Brovincamine

Brovincamine is an orally active slow Ca²⁺ channel blocker and vasodilator. Brovincamine reduces Ca²⁺ influx across the plasma membrane by blocking Ca²⁺ channels. Brovincamine inhibits catecholamine secretion, cholinergic function, autonomic parasympathetic nervous system activity, cerebrovascular resistance, and nerve stimulation-induced convulsive responses. Brovincamine induces cerebrovascular, coronary, and intracranial vasodilation, improves cerebral cortical microcirculation, enhances cerebral metabolic activity, and increases capillary clearance efficiency. Brovincamine can be used in research related to cerebral ischemic diseases, cardiac ischemic diseases, and normal-tension glaucoma^[1][2][3][4]. In Vitro:Brovincamine (30-100 μM; 10 min) inhibits Carbamoylcholine (HY-B1208)-induced (IC₅₀ 30 μM) and high K⁺-induced (IC₅₀ 100 μM) catecholamine secretion and calcium influx in cultured bovine adrenal chromaffin cells, and its inhibitory characteristics vary with extracellular Ca²⁺ concentration depending on the secretagogue^[1]. In Vivo:Brovincamine (6.4 mg/kg; intravenous injection; single administration) mildly inhibits the cardiovascular response to DMPP in spinal dogs^[2].
Brovincamine (2-4 mg/kg, intravenous injection; single/cumulative administration) slightly but dose-dependently inhibits ganglionic stimulant-induced tachycardia in spinal dogs^[2].
Brovincamine (7.5 mg/kg/day; p.o.; daily administration; for 4 weeks) improves cortical cerebral capillary morphology in young adult rats and aged healthy rats by increasing the volume, length, and density of cortical cerebral capillaries while decreasing capillary diameter and intercapillary distance^[4].