(±)-Nornicotine
CAS No. : 5746-86-1
(Synonyms: Nornicotine)
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| Cat. No. : | HY-W002112 |
| M.Wt: | 148.20 |
| Formula: | C9H12N2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
(±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia[1][2][3][4].
In Vitro: (±)-nornicotine (0.08-0.16 ng/mL; 24 h) promotes cell migration, disrupts adherens junctions (β-catenin) and tight junctions (ZO-1), and induces F-actin depolymerization in EA.hy926 human endothelial cells[2].
In Vivo: (±)-nornicotine (0.075-0.6 mg/kg/infusion; intravenous self-administration via jugular catheter) maintains self-administration behavior with rates significantly higher than saline in Sprague-Dawley rats[3].
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