Resiniferatoxin

Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period^[1][2]. In Vitro: Resiniferatoxin causes extremely prolonged channel opening and calcium influx, which results in cytotoxicity to the TRPV1-positive pain fibers or cell bodies^[1]. In Vivo: Resiniferatoxin (2 μg/10 μl; injected intrathecally into the T2/T3 interspace; four weeks after coronary artery occlusion to induce heart failure in rats) significantly and selectively abolishes the afferent markers expression (TRPV1 and calcitonin gene-related peptide) in dorsal horn and reduced overactivated CSNA. Resiniferatoxin significantly reverses the prolongation of action potential duration (APD) and APD alternan, reduces the inducibilities of ventricular arrhythmias^[2].