6-Thioinosine
CAS No. : 574-25-4
(Synonyms: 6TI; 6-Mercaptopurine riboside)
| Size | Price | Stock |
|---|---|---|
| 250mg | $43 | In-stock |
| 1g | $106 | In-stock |
| 5g | $405 | In-stock |
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| Cat. No. : | HY-128671 |
| M.Wt: | 284.30 |
| Formula: | C10H12N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction[1].
In Vitro:6-Thioinosine (1-50 µM, once every 3 days for 9 days) reduces lipid and triglyceride accumulation and GPDH activity, increases TNF α production in 3T3-L1 cells[1].
6-Thioinosine (1-25 µM, 2-14 h/once every 3 days for 9 days) inhibits the expression and transactivation activity of PPAR γ, induces NO production by upregulating the iNOS gene, induces iNOS expression by activating JNK in 3T3-L1 cells[1].
6-Thioinosine (1-25 µM, once every 3 days for 21 days) exerts an anti-adipogenic effect on adipose tissue-derived stem cells and presdipocytes[1].
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