15-Deoxy-Δ12,14-prostaglandin A1
CAS No. : 573951-20-9
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| 1mg | $360 | Get quote |
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| Cat. No. : | HY-118101 |
| M.Wt: | 318.45 |
| Formula: | C20H30O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].
In Vitro: 15-Deoxy-Δ12,14-prostaglandin A1 (25, 50 μM; 2 h) inhibits TNF-α-induced IκB-α kinase (IKK) activation, IκB-α degradation, and NF-κB/p65 translocation while promoting AP -1/c-Jun phosphorylation [1].
15-Deoxy-Δ12,14-prostaglandin A1 (25 μM; 2 h) enhances TNF-α-induced cell death in HAEC and HUVEC [1].
15-Deoxy-Δ12,14-prostaglandin A1 (10 μM; 2 h) inhibits TNF-α-induced monocyte arrest [1].
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