Tacalcitol
CAS No. : 57333-96-7
(Synonyms: 1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3)
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $430 | In-stock |
| 10mg | $690 | In-stock |
| 25mg | $1370 | In-stock |
| 50mg | $2190 | In-stock |
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| Cat. No. : | HY-32337 |
| M.Wt: | 416.64 |
| Formula: | C27H44O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].
In Vitro:Tacalcitol (0.1-100 μM, 24 h) inhibits synthesis of both IL-6 and IL-8 in cultures derived from nasal polyps in dose-dependent manner[1].
Tacalcitol (10-4-1 μM, 48 h or one week) induces cell differentiation in normal human keratinocytes. Tacalcitol inhibits the growth of normal and psoriatic human keratinocytes[2][3].
Tacalcitol (0-1 μM, 48 h) inhibits DNA synthesis in normal human keratinocytes[3].
Tacalcitol (0.001-10 μM, 6 days) strongly reduces proliferation of human glioblastoma[4].
Tacalcitol (10 μM, 41 h) inhibits human glioblastoma migration[4].
In Vivo:Tacalcitol (0.2-20 μg/g; applied to the cutaneous inflammation area) ointment has a marked effect on cutaneous inflammation caused by TPA, and improves effect on epidermal differentiation in hairless mice[5].
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