Felbinac
CAS No. : 5728-52-9
(Synonyms: 4-Biphenylacetic acid)
| Size | Price | Stock |
|---|---|---|
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| 100g | $33 | In-stock |
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| Cat. No. : | HY-B0641 |
| M.Wt: | 212.25 |
| Formula: | C14H12O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming) |
Felbinac is a metabolite of fenbufen, an orally active nonsteroidal anti-inflammatory agent and a cyclooxygenase (COX) inhibitor with an IC50 of 865.68 nM for COX1 and 976 nM for COX2. Felbinac reduces the production of prostaglandins by inhibiting COX to relieve pain, reduce inflammation and reduce fever. Felbinac can inhibit CHIKV viral activity[2][3][4].
In Vitro:Felbinac (1.56 and 3.125μM; 24 h) inhibited CHIKV in Vero CLL-81 cells with an IC50 of 0.238 μM, a CC50 of 525 μM and an SI of 2205[2].
In Vivo:Felbinac (50 mg/kg; intraperitoneal; single dose) alone do not cause convulsions in mice and has no effect on fatty acid metabolism and glucose metabolism[3].
Felbinac (20, 60 mg/kg; oral; single dose) has anti-inflammatory, analgesic and ulcerogenic activities in rats and mice[4].
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