Calmidazolium (chloride)
CAS No. : 57265-65-3
(Synonyms: R 24571)
| Size | Price | Stock |
|---|---|---|
| 5mg | $72 | In-stock |
| 10mg | $110 | In-stock |
| 50mg | $275 | In-stock |
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| Cat. No. : | HY-103319 |
| M.Wt: | 687.70 |
| Formula: | C31H23Cl7N2O |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively[1]. Also in anti-cancer research[2]. Calmidazolium binds to calmodulin with a Kd of 3 nM. IC50 & Target:Kd: 3 nM (Calmodulin)[3] In Vitro: Calmidazolium chloride is widely used as a calmodulin (CaM) antagonist, but is also known to induce apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits growth of mouse F9 ECCs[2].
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