Pamidronate (disodium)
CAS No. : 57248-88-1
(Synonyms: CGP 23339A)
| Size | Price | Stock |
|---|---|---|
| 5mg | $46 | In-stock |
| 10mg | $72 | In-stock |
| 25mg | $130 | In-stock |
| 50mg | $208 | In-stock |
| 100mg | $212 | In-stock |
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| Cat. No. : | HY-B0012A |
| M.Wt: | 279.03 |
| Formula: | C3H9NNa2O7P2 |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
Pamidronate disodium (CGP 23339A), the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
In Vitro:Pamidronate disodium (0.001-1000 µM, 72 h) inhibits the cell viability of osteosarcoma cells POS, HMPOS and COS31, exhibits no cytotoxicity to fibroblasts[1].
In Vivo:Pamidronate disodium (3 mg/kg, ear vein injection, once monthly for 14 weeks) improves the bone structure, alleviates the degenerative changes of cartilage, exhibits protective effect against osteoarthritis in rabbit models[3].
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