Norfluoxetine (hydrochloride)
CAS No. : 57226-68-3
| Size | Price | Stock |
|---|---|---|
| 10mg | $93 | In-stock |
| 50mg | $211 | In-stock |
| 100mg | $314 | In-stock |
| 250mg | $508 | In-stock |
| 500mg | $896 | In-stock |
| 1g | $1671 | Get quote |
| 5g | $5912 | Get quote |
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| Cat. No. : | HY-W011235 |
| M.Wt: | 331.76 |
| Formula: | C16H17ClF3NO |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Norfluoxetine hydrochloride is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity[1][2][3][4]. In Vivo: Pretreatment with Fluoxetine or Norfluoxetine hydrochloride (20mg/kg s.c.), as well as Phenytoin (30 mg/kg s.c.) and Clonazepam (0.1mg/kg s.c.) significantly increases both the rate and duration of survival, demonstrating a significant protective effect against Pentylenetetrazol-induced epilepsy[1].
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