Proglumetacin
CAS No. : 57132-53-3
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| Cat. No. : | HY-106560 |
| M.Wt: | 844.43 |
| Formula: | C46H58ClN5O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Proglumetacin is an orally active and potent cyclo-oxygenase inhibitor. Proglumetacin can inhibits SARS-CoV Mpro (main protease of the SARS-CoV-2), with an AC50 of 8.9?μM (activity concentration at half maximal activity). Proglumetacin has anti-inflammatory activity, can be used for inflammation (such as Rheumatoid arthritis, and Allergic air pouch inflammation) research[1][2][3].
In Vitro: Proglumetacin strongly inhibits 5-HETE formation, with an IC50 of 1.5 μM[2].
Proglumetacin inhibits leukocyte migration by inhibiting the production of the chemotactic cyclo-oxygenase product thromboxane B2[2].
In Vivo: Proglumetacin (Sprague-Dawley rats, 0-30 mg/kg, Orally, once) dose-dependently inhibits accumulation of pouch exudate[1].
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