Laropiprant
CAS No. : 571170-77-9
(Synonyms: MK-0524)
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $680 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-50175 |
| M.Wt: | 435.90 |
| Formula: | C21H19ClFNO4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Laropiprant is a potent and selective DP receptor antagonist with Ki values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively[1][2][3].
IC50 & Target:Ki: 0.57 nM (DP receptor)[1]
In Vitro:Laropiprant (0.01-1000 μM; 10 mins; HEK293 cells) is an inverse agonist of DP1 cAMP signaling and reduces DP1 cAMP signaling below basal levels[1].
Laropiprant (1 μM; 0-24 h; HEK293 cells) is a pharmacochaperone in promoting DP1 cell surface expression[1].
In Vivo:Laropiprant (0-100 mg/kg; p.o. and i.v.; male Sprague-Dawley rats) exhibits good pharmacokinetic profiles[3].
Pharmacokinetic Analysis in Male Sprague-Dawley rats[3]
| Route | Dose (mg/kg) | AUC0-∞ (μM·hr) | Clp (mL/min/kg) | Vdss (L/kg) | T1/2 (hr) |
| PO | 1 | 22.7 | 1.9 | 0.7 | 7.4 |
| PO | 5 | 96.0 | 2.1 | 0.9 | 7.6 |
| Route | Dose (mg/kg) | AUC0-∞ (μM·hr) | Cmax (μM) | Tmax (hr) | F(%) |
| IV | 5 | 52.6 | 15.6 | 1.2 | / |
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