ALX-5407
CAS No. : 571147-18-7
(Synonyms: (R)-NFPS)
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| Cat. No. : | HY-10711 |
| M.Wt: | 393.45 |
| Formula: | C24H24FNO3 |
| Purity: | >98 % |
| Solubility: |
ALX-5407 ((R)-NFPS) is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1]. In Vitro:ALX-5407 (0-1 mM) GlyT1- or GlyT2-dependently inhibits glycine transport and blocks [3H]glycine uptake in rat brain and QT6-1C cells with an IC50 value of 3 nM[1]. ALX-5407 (50 nM) shows slow dissociation kinetics in QT6-1C cells[1]. In Vivo:ALX-5407 (1 and 10 mg/kg; oral administration, once) increases free glycine levels in rat prefrontal cortex[1].
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