Maytansinol
CAS No. : 57103-68-1
(Synonyms: Ansamitocin P-0)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $600 | In-stock |
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| Cat. No. : | HY-19474 |
| M.Wt: | 565.06 |
| Formula: | C28H37ClN2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 35 mg/mL |
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit tubulin polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research[1][2].
In Vitro: Maytansinol (0.09-0.75 nM, 24 h) decreases the growth and survival of HCT116 cells in a dose-dependent manner [2].
In Vivo: Maytansinol (2 μM, 10 μM, add to food, 1-2 h) can depolymerize microtubules in Drosophila. Maytansinol (0.5-2 μM, add to food, 10 days) decreases the survival rate of wild-type and p53 mutant larvae. Maytansinol (1 or 2 μM, add to food, 24-26 h) can induce apoptosis of wild-type Drosophila cells[2].
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