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DMBA


CAS No. : 57-97-6

(Synonyms: 7,12-DMBA; 7,12-Dimethylbenzanthracene)

57-97-6
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Cat. No. : HY-W011845
M.Wt: 256.35
Formula: C20H16
Purity: >98 %
Solubility: Ethanol : 3.33 mg/mL (ultrasonic;warming;heat to 60°C);Acetone : 25 mg/mL (ultrasonic);DMSO : 25 mg/mL (ultrasonic)
Introduction of 57-97-6 :

DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models[1]. In Vivo:DMBA can be used in animal modeling to construct chemically induced skin carcinogenesis, breast cancer and other cancer models.
DMBA (0-150 mg/kg, p.o.) results in a decrease in spleen weight and in the total lymphocytes recovered from the spleen in C57BL/6 mice. DMBA exhibits a terminal deposition half-life of 45 min at all dose ranges (5-50 mg) in SD rats[5]. DMBA (0-150 mg/kg, p.o.) results in a decrease in spleen weight and in the total lymphocytes recovered from the spleen in C57BL/6 mice. DMBA exhibits a terminal deposition half-life of 45 min at all dose ranges (5-50 mg) in SD rats[5].

1. Induction of breast cancer[2]

Background
DMBA activates AhR, which translocates into nucleus and dimerizes with cofactor ARNT, thus induces the expressions of protooncogenes c-myc.
Specific Mmodeling Methods
Rat: Sprague-Dawley • female • 50 days •140-150 g
Administration: 15-20 mg DMBA • intragastric gavage • single dose
Note
1.5-2 g DMBA dissolved in 100 ml sesame oil
Modeling Record
Palpation:Detection of mammary cancer in 150 days.
Histology analysis:The tumor exhibits tightly spaced chords epithelial cells, cysts and papillary structures.
Phenotype:develops a temporary cessation in body growth.
Correlated Product(s): Phytic acid (HY-N0814); Limonene (HY-N0544)

2. Induction of skin cancer[3]

Background
DMBA is metabolized to reactive intermediates, such as syn- and anti-diol epoxides, and binds extensively to epidermal DNA.
Specific Mmodeling Methods
European hamster: • 10 weeks • 180-200 g •
Administration: 25 mg DMBA • applied on the shaved back skin • single dose
Note
25 mg DMBA is dissolved in 1 ml acetone
Modeling Record
Histological analysis: Epidermal hyperplasia is oberserved. Lesions occurred frequently in the back skin, such as trichoepitheliomas, neoplastic epidermal cysts and melanotic tumors
Correlated Product(s): α-Mangostin (HY-N0328); DHEA (HY-14650); Salidroside (HY-N0109)

3. Induction of lung cancer[4]

Background
DMBA is metabolized by cytochrome P450 enzymes into the carcinogenic form 7,12-DMBA-3,4-dihydrodiol-1,2- epoxide, which adducts with DNA and produces mutations.
Specific Mmodeling Methods
BALB/c mice: •12 weeks • 25-35 g • 5-20 mg/kg • intratracheal instillation • single dose.
Note
(1). 5-20 mg DMBA is dissolved in 0.2 ml saline.
(2). A coat of antibiotic is applied after the instillation.
Modeling Record
Molecular changes:Increased number of macrophages in the broncho-alveolar lavage (BAL) fluid and levels of malonyldialdehyde (MDA) in lung tissue.
Histology analysis:Inflammation with alveolar epithelial hyperplasia, adenic metaplasia, adenomatoid hyperplasia and atypical hyperplasia.
Correlated Product(s): Diclofenac (HY-15036)

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