Progesterone

CAS No. : 57-83-0

(Synonyms: Pregn-4-ene-3,20-dione)

Price and Availability of CAS No. : 57-83-0


Size	Price	Stock
100mg	$66	In-stock
1g	$79	In-stock
5g	$106	In-stock
10 g		Get quote
50 g		Get quote
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Cat. No. :	HY-N0437
M.Wt:	314.46
Formula:	C21H30O2
Purity:	>98 %
Solubility:	DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C)

Introduction of 57-83-0 :

Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Progesterone can be used to create melasma models^[6].

Induction of Chloasma^[6]

Background

Progesterone increases the pigmentation and body weight. The body weight gain was believed to be due to sodium and fluid retention, which may further affect the intracellular pH of melanosomes, which synthesize melanin, in turn, leading to melanin production because tyrosinase activity is linked to the intracellular pH environment^[7].

Specific Modeling Methods

Mice: 6-8 weeks, female C57BL/6J mice
Administration: 15 mg/kg; Injected intramuscularly, daily for 30 days

Note

Selected 3*3 cm² area on the back of mice, shaved the hair, and then irradiated with UVB (λ=312 nm, 2 h/day).

Modeling Indicators

Phenotypic changes: cutaneous tissue injury, scab format, skin got blacker. Tissue changes: hair follicles necrosis, fibrous tissue hyperplasia, epidermal melanocyte enrichment. Molecular changes: p-JNK /JNK, p-P38MAPK/P38MAPK ↑.

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Progesterone

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