Sulfaguanidine
CAS No. : 57-67-0
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|---|---|---|
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| Cat. No. : | HY-B1267 |
| M.Wt: | 214.24 |
| Formula: | C7H10N4O2S |
| Purity: | >98 % |
| Solubility: | H2O : 3.33 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery[1][2].
In Vivo: Sulfaguanidine (2.5 mg/kg; i.v.) exhibits CLt (adult 0.29, neonate 0.14 L/h/kg), AUC0-∞ (adult 8.18, neonate 20.46 μg•h/mL), and Vdss (adult 0.65, neonate 0.59 L/kg) in rats[3].
Sulfaguanidine (2.5 mg/kg; p.o.) exhibits absolute bioavailability (adult 12.76%, neonate 57.86%), Cmax (adult 0.41, neonate 3.56 μg/mL), and Tmax (adult 1.67, neonate 1.50 h) in rats[2].
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