6-Acetamidohexanoic acid

6-Acetamidohexanoic acid (Acexamic acid; 6-Acetamidocaproic acid) is a metabolite of Hexamethylene bisacetamide (HMBA) (HY-124284) with anti-pulmonary fibrosis activity. 6-Acetamidohexanoic acid does not induce differentiation of human promyelocytic leukemia cells, but is taken up by such cells. 6-Acetamidohexanoic acid serves as a carboxylic acid substrate component for constructing carboxylesterase-responsive near-infrared phototheranostic probes. 6-Acetamidohexanoic acid is applicable to research related to pulmonary fibrosis, refractory hypoxemia and cervical cancer^[1][2][3]. In Vitro: 6-Acetamidohexanoic acid can be covalently conjugated with the hemicyanine dye HCH via an ester bond to form the phototheranostic probe HCH-AcAH. When the probe enters tumor cells with overexpressed carboxylesterase (CES) (HeLa cells), CES specifically hydrolyzes the ester bond between Acexamic Acid and the dye. Cleavage of the ester bond releases the active dye molecule, which generates a strong near-infrared fluorescent signal for tumor imaging and simultaneously produces reactive oxygen species for photodynamic theranostics^[2].
6-Acetamidohexanoic acid (0.5-5 mM) shows no activity in inducing the differentiation of human promyelocytic leukemia HL-60 cells even at concentrations up to 5 mM^[3].