NSC-87877
CAS No. : 56990-57-9
| Size | Price | Stock |
|---|---|---|
| 10mg | $35 | In-stock |
| 25mg | $79 | In-stock |
| 50mg | $131 | In-stock |
| 100mg | $219 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18756 |
| M.Wt: | 459.45 |
| Formula: | C19H13N3O7S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 23.81 mg/mL (ultrasonic;warming;heat to 60°C) |
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC50 values of 0.318 μM, 0.355 μM shp2 and shp1, respectively[1]. NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26)[2]. IC50 & Target:IC50: 0.318 μM (shp2), 0.355 μM (shp1)[1]. In Vitro: NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines[3].
NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation[3].
In Vivo: NSC-87877 (30 mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity[3].
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