U-46619
CAS No. : 56985-40-1
(Synonyms: 9,11-Methanoepoxy PGH2)
| Size | Price | Stock |
|---|---|---|
| 28.5 mM * 1 mL in Methyl acetate | $1585 | In-stock |
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| Cat. No. : | HY-108566 |
| M.Wt: | 350.49 |
| Formula: | C21H34O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of Thromboxane A2 (HY-113350) (TXA2) and acts as a potent TXA2 (TP) agonist. U-46619 also is a RhoA agonist. U-46619 stimulates the activation of RhoA through TXA2 receptor activation[1][4][5].
IC50 & Target:TXA2[1]
In Vitro: U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1].
U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1].
U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1].
U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2].
In Vivo: U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3].
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