Gabexate (mesylate)

Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation^[1][2][3][4]. In Vitro:Gabexate mesylate (FOY; 100-1000 μM; 72 hours) decreases The proliferation rate in a dose-dependent manner^[3]. In Vivo:Gabexate mesylate (FOY; 20 mg/kg; Intraperitoneally; daily; from 3rd day until the 14th day) attenuates the development of mechanical allodynia induced by spinal nerve ligation (SNL). Gabexate mesylate has an inhibitory effect on the expressions of pro-inflammatory cytokines after SNL for a short-term period^[4].