(E/Z)-Platyphyllenone

(E/Z)-Platyphyllenone is a diarylheptanoid compound that can be found in Alnus viridis ssp. viridis. (E/Z)-Platyphyllenone inhibits the biosynthesis of violacein, but stimulates the production of AHL and AHQ quorum-sensing signal molecules as well as the synthesis of pyocyanin in Pseudomonas aeruginosa PAO1, and exhibits strong cytotoxicity against human lung fibroblasts. (E/Z)-Platyphyllenone can be used in studies on Pseudomonas aeruginosa^[1]. In Vitro:(E/Z)-Platyphyllenone (Compound 7) (0.5 MIC; 24 h) does not inhibit early biofilm formation in Pseudomonas aeruginosa PAO1^[1].
(E/Z)-Platyphyllenone (10-15 µg/mL) reduces twitching and swimming motility in Pseudomonas aeruginosa PAO1^[1].
(E/Z)-Platyphyllenone (50 µg/mL; 24 h) stimulates pyocyanin production to 127% of control levels in Pseudomonas aeruginosa PAO1^[1].
(E/Z)-Platyphyllenone (100 µg per disc) inhibits violacein production in Chromobacterium violaceum CV026^[1].
(E/Z)-Platyphyllenone (50 µg/mL; 24 h) stimulates 2-alkyl-4-quinolones production to 150% of control levels (50% relative increase) in Pseudomonas aeruginosa PAO1^[1].
(E/Z)-Platyphyllenone (1-100 µg/mL; 48 h) exhibits concentration-dependent antiproliferative activity against MRC5 human lung fibroblasts, with an IC₅₀ of 70 µg/mL, inhibiting proliferation by ~95% at both 50 µg/mL and 100 µg/mL^[1].