Carcinine
CAS No. : 56897-53-1
(Synonyms: β-Alanylhistamine)
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| Cat. No. : | HY-107567 |
| M.Wt: | 182.22 |
| Formula: | C8H14N4O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Carcinine (β-Alanylhistamine) is a selective and orally active histamine H3 receptor antagonist with a Ki of 0.2939 μM. Carcinine can reduce histamine content. Carcinine exhibits anti-oxidant activity and neuroprotective effects. Carcinine shows positive inotropic effect and can reduce blood sugar and blood lipid levels. Carcinine can be used for the researches of inflammation, neurological, cardiovascular and metabolic disease, such as retinal damage, seizure and diabetes[1][2][3][4][5].
In Vitro:Carcinine (0.5 mM, 16 h) forms a stable adduct with 4-HNE (HY-113466) a retention time of 17.5 mins[1].
Carcinine (1 μg-2 mg, 90 mins) inhibits 4-HNE-induced modification of mouse retinal proteins with an IC50 of 33.2 μg/μL[1].
Carcinine (1 mg, 0-72 h) reverses pre-formed 4-HNE-retinal protein adducts[1].
Carcinine (5 mM, 4-8 h) rescues the protein level of retinol dehydrogenase 12 in mouse retinal explants treated with 4-HNE[1].
Carcinine shows high affinity for histamine H3 receptor (Ki = 0.2939 μM) and extremely low affinity for H1 (Ki = 3621.2 μM) and H2 (Ki = 365.3 μM) receptors[2].
Carcinine (2-50 μM, 22.5 mins) increases K+-induced endogenous 5-HT release but shows no effect on dopamine release in mouse forebrain slices[2].
Carcinine (10 mM) scavenges hydroxyl radicals and inhibits deoxyribose damage[3].
Carcinine (10-25 mM, 60 mins) reduces linoleic acid 13-monohydroperoxide (LOOH) and phosphatidylcholine hydroperoxide (PCOOH) in PC liposomes to hydroxy products (LOH)[3].
In Vivo:Carcinine (2 M, 1 μL per eye, intravitreally injection, 48 h recovery before light exposure) protects retinal photoreceptors in BALB/c mice with bright light exposure[1].
Carcinine (0.2-20 mg/mouse, i.g., daily for 5 days) protects the retina in BALB/c mice with bright light exposure[1].
Carcinine (5-50 mg/kg, i.p.) decreases cortical and midbrain histamine content in ICR mice[2].
Carcinine (2-20 mg/kg, i.p., before PTZ) significantly reduces the seizure stage induced by pentylenetetrazole (PTZ) in ICR mice[2].
Carcinine (10-20 mg/kg, i.p., 30 mins before scopolamine) significantly ameliorates Scopolamine (HY-N0296)-induced learning deficit in ICR mice[2].
Carcinine (10-50 mg/kg, i.p.) increases the total ambulation distance in ICR mice[2].
Carcinine (10-100 μg, heart injection via perfusate cannula) shows positive inotropic effect in guinea pigs[4].
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