Hemopressin(rat)
CAS No. : 568588-77-2
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|---|---|---|
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| 5mg | $60 | In-stock |
| 10mg | $105 | In-stock |
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| Cat. No. : | HY-P1090 |
| M.Wt: | 1088.26 |
| Formula: | C53H77N13O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models[1][2].
In Vivo: Hemopressin(rat) causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)[1].
Oral administration of Hemopressin(rat) inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin(rat) treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats[2].
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