AZD2098
CAS No. : 566203-88-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $83 | In-stock |
| 10mg | $149 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $675 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00064 |
| M.Wt: | 334.18 |
| Formula: | C11H9Cl2N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);Ethanol : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
AZD2098 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research[1][2].
IC50 & Target: pIC50: 7.8 (hCCR4), 8.0 (rat CCR4), 8.0 (mouse CCR4), 7.6(dog CCR4)[1]
In Vitro: AZD2098 potently inhibits chemokine-induced cellular responses, with pIC50 of 7.5 and 6.3 against CCL22-induced Ca2+ influx in hCCR4-expressing CHO cells and CCL17- or CCL22-induced chemotaxis of primary human Th2 cells respectively[1].
In Vivo: AZD2098 (73.5-5.0 μg/kg; p.o.; BID; twice a day; 1 hour before and every 12 hours after antigen challenge) exhibits efficacy against antigen-induced inflammatory response among ovalbumin-sensitized rats, and the changes are first visible at a dose of 0.22 µmol/kg and maximal at 7.5 µmol/kg[1].
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