7-Ketocholesterol
CAS No. : 566-28-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $43 | In-stock |
| 10mg | $65 | In-stock |
| 25mg | $140 | In-stock |
| 50mg | $234 | In-stock |
| 100mg | $410 | In-stock |
| 250mg | $698 | In-stock |
| 1g | $2134 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-113342 |
| M.Wt: | 400.64 |
| Formula: | C27H44O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 6.25 mg/mL (ultrasonic;warming;heat to 60°C) |
7-Ketocholesterol is an oxidation product of cholesterol, widely present in atherosclerotic plaques, and has a stronger atherogenic effect than cholesterol. 7-Ketocholesterol can inhibit the rate-limiting enzymes involved in bile acid and cholesterol synthesis, such as cholesterol 7α-hydroxylase and HMG-CoA reductase. 7-Ketocholesterol exhibits pro-inflammatory effects both in vivo and in vitro and can induce cell apoptosis (apoptosis)[1]. In Vitro: 7-Ketocholesterol (50 μM, 2.5-2 hours) can enhance leukocyte-endothelial cell adhesion via the p38 MAPK pathway[4]. 7-Ketocholesterol (2.5-40 μg/mL, 24 hours) induces apoptosis in a dose-dependent manner by activating caspase-3/7, -8, and -12 in human microvascular endothelial cells[5]. In Vivo: 7-Ketocholesterol (5-20 mg/mL, administered via biodegradable wafers implanted into the anterior chamber of rats' eyes, single dose) exhibited pro-angiogenic and pro-inflammatory effects in Brown Norway rats[1].
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- 7-Ketocholesterol
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