RXPA 380
CAS No. : 564479-79-4
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| Cat. No. : | HY-18205 |
| M.Wt: | 617.63 |
| Formula: | C33H36N3O7P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RXPA 380 is a C-terminal specific angiotensin-converting enzyme (ACE) inhibitor with a Ki of 3 nM. RXPA 380 inhibits C-domain mutants of human recombinant ACE with an IC50 of 2.5 nM[1].
IC50 & Target:Ki: 3 nM (C-terminal ACE), 10 μM (N-terminal ACE)[1]
IC50: 2.5 nM (C-domain mutants of human recombinant ACE), 10 μM (N-domain mutants of human recombinant ACE)[1]
In Vitro:RXPA 380 shows Ki(app) values of 12 nM and 12 μM for the C- and N-domain of mouse somatic ACE[1].
In Vivo:RXPA 380 (0.9-30 mg/kg; i.v.; once) inhibits ACE activity in mice[1].
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