Oxybutynin

Oxybutynin is an anticholinergic agent, which inhibits vascular K_v channels in a concentration-dependent manner, with an IC₅₀ of 11.51 μM^[1]. Oxybutynin is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. In Vitro: Oxybutynin (0.1, 0.3, 1, 3, 10, 30, 100 μM; 200 ms) inhibits vascular Kv channels in a concentration-dependent manner independent of anticholinergic effect in coronary arterial smooth muscle cells^[1]. In Vivo: Oxybutynin (27.2 mg/kg; p.o.; single) exhibits significant binding of mouse brain muscarinic receptors that about a 2-fold increase in K_d values for specific [³H]N-methylscopolamine binding 0.5 and 2 h later^[2].