8-Hydroxyguanine
CAS No. : 5614-64-2
(Synonyms: 8-Oxoguanine; 8-oxo-Gua)
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|---|---|---|
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| 10mg | $304 | In-stock |
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| Cat. No. : | HY-113338 |
| M.Wt: | 167.13 |
| Formula: | C5H5N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C);1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 12 with 1M NaOH);H2O : 4.72 mg/mL (ultrasonic;warming;adjust pH to 11 with NaOH;heat to 60°C) |
8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage[1][2]. In Vitro: The most common product of ROS-induced base damage is 8-Hydroxyguanine. Failure to promptly remove 8-Hydroxyguanine often causes mutations during DNA replication. 8-Hydroxyguanine is cleared from cells by the 8-oxoG DNA glycosylase 1 (OGG1)-mediated oxidative damage base excision repair pathway so as to prevent cells from suffering dysfunction due to oxidative stress[2].
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