4-Hydroxylonchocarpin
CAS No. : 56083-03-5
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| 10mg | $514 | In-stock |
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| Cat. No. : | HY-N2208 |
| M.Wt: | 322.36 |
| Formula: | C20H18O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
4-Hydroxylonchocarpin is a chalcone compound. 4-Hydroxylonchocarpin enhances the phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin induces reactive oxygen species (ROS) and apoptosis in liver cancer cells. 4-Hydroxylonchocarpin has various pharmacological activities, including antibacterial, anticancer, anti-retroviral, anti-tuberculosis, anti-malarial and anti-inflammatory activities[1][2].
In Vitro:4-Hydroxylonchocarpin (7.5-30 μM) reduces the oxidation activity of L-DOPA in B16F10 cells in a dose-dependent manner[1].
4-Hydroxylonchocarpin (15 μM, pretreated for 30 min-3 h) reduces α-MSH and IBMX-induced tyrosinase activity in B16F10 cells[1].
4-hydroxylonchocarpin causes hepatocyte injury and apoptosis by inducing oxidative stress and mitochondrial dysfunction in HepG2 cells[2].
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