Sucralose

Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents^[1][2]. In Vivo:The results show that Sucralose induces significant increased incidence of all hematopoietic neoplasias in male mice exposed to 2,000, and 16,000 ppm, with a significant dose-related relationship. Microscopically, most of the neoplasias among male mice treated with Sucralose at 2,000 to 16,000 ppm are leukemias involving lungs, liver, spleen, lymph nodes, and bone marrow with diffuse permeation of vessels and extensive infiltration of adjacent tissues^[1].