Fomepizole (hydrochloride)
CAS No. : 56010-88-9
(Synonyms: 4-Methylpyrazole (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 100mg | $62 | In-stock |
| 250mg | $107 | In-stock |
| 1g | $284 | In-stock |
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| Cat. No. : | HY-B0876A |
| M.Wt: | 118.56 |
| Formula: | C4H7ClN2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fomepizole (4-Methylpyrazole) hydrochloride is a potent and orally active cytochrome P450 (CYP2E1) inhibitor. Fomepizole hydrochloride is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole hydrochloride blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole hydrochloride has the potential for an antidote for ethylene glycol or methanol poisoning[1][2][3]. In Vivo: Pretreatment with Fomepizole (4-Methylpyrazole; 25 mg/kg; IP) prolongs ethanol neurobehavioral toxicity in CD-1 mice[4]
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