Have any questions? [email protected] +86-21-58998590
Structure search

Histamine (dihydrochloride)


CAS No. : 56-92-8

56-92-8
Price and Availability of CAS No. : 56-92-8
Size Price Stock
10g $15 In-stock
25g $26 In-stock
100g $69 In-stock
500g $178 In-stock
1000g $333 In-stock
> 2 kg Get quote
We match the lowest price on market.

We offer a substantial discount on larger orders, please inquire via [email protected]

or Fax: (86)21-58955996

Inquiry for price and availability only. Please place your order via our email or fax.

Cat. No. : HY-B0722
M.Wt: 184.07
Formula: C5H11Cl2N3
Purity: >98 %
Solubility:
Introduction of 56-92-8 :

Histamine dihydrochloride is the agonist for histamine receptor and a vasodilator. Histamine dihydrochloride is an organic nitrogen compound that participates in local immune responses, regulates intestinal physiological functions, and acts as a neurotransmitter. Histamine dihydrochloride affects p38 MAPK/Akt signaling pathway, exhibits antitumor, antioxidant and anti-inflammatory activities. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2][3][4][5][6][7]. In Vitro:Histamine dihydrochloride (0.01-10 μM, 72 h) exhibits a bidirectional regulatory effect on the proliferation of MDA-MB-231, arrests the cell cycle at G2/M phase, induces the formation of lipid droplet, induces differentiation and apoptosis in MDA-MB-231[4].
Histamine dihydrochloride (10 μM, 24 h) increases the generation of ROS, especially H2O2, reduces the activity of antioxidant enzymes (such as catalase), thereby promoting radiosensitivity in MDA-MB-231[4].
Histamine dihydrochloride (1-100 μM, 12 h) inhibits the migration of microglia and the release of inflammatory mediator IL-1β in LPS (HY-D1056)-stimulated N9 mouse microglial, exhibits anti-inflammatory activity[5]. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Histamine (0.05-100 μg/mouse, icv, single dose) exhibits analgesic effect at high doses of histamine (50-100 μg/mouse), causes hyperalgesia at low doses (0.1-1 μg/mouse) in mouse model[3].
Histamine dihydrochloride (62.5-2000 μg; Intravaginal injection) can exert a similar effect to estrogen in ovariectomized mice, causing a decrease in intravaginal tetrazolium, an increase in epithelial growth, and keratinization[6].
Histamine can be used in animal modeling to create gastrointestinal ulcer models[1].

Induction of Gastrointestinal Ulcer[1]
Background
Histamine can cause increased gastric acid secretion, decreased mucus production, reflux of pancreatic juice, poor gastric blood flow, and thus gastric ulcers. Stress can cause increased gastrointestinal motility, making the gastric folds more susceptible to damage when exposed to acid.
Specific Modeling Methods
Guinea Pig: male • albino • Administration: 5 mg/kg • i.p. • single dose
Note
(1) No eating or drinking is allowed 24 hours before the experiment.
(2) The animals are sacrificed 2 hours after histamine injection, and treated with 1% formalin to check for gastric ulcers.
Modeling Indicators
The ulcers were punctate or elongated. After the model was dissected, the ulcer index (the sum of the lengths of the lesions) was measured under a microscope to be 3.4 mm.
Correlated Product(s): Serotonin (HY-B1473A); Reserpine (HY-N0480)
Opposite Product(s): Cimetidine (HY-14289)

Your information is safe with us.