ATP
CAS No. : 56-65-5
(Synonyms: Adenosine 5'-triphosphate)
| Size | Price | Stock |
|---|---|---|
| 10g | $19 | In-stock |
| 25g | $31 | In-stock |
| 100g | $122 | In-stock |
| 500g | $432 | In-stock |
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| Cat. No. : | HY-B2176 |
| M.Wt: | 507.18 |
| Formula: | C10H16N5O13P3 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 100 mg/mL |
ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice[1][2][3][4].
In Vitro:ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP (2mM) promotes neutrophil chemotaxis[4].
In Vivo:ATP (50 mg/kg; i.p., 1-24 h before bacterial challenge) protects mice against bacterial infection in mice, such as E. coli and S. aureus[4].
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