Deoxycorticosterone acetate
CAS No. : 56-47-3
(Synonyms: 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate)
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| Cat. No. : | HY-B1472 |
| M.Wt: | 372.50 |
| Formula: | C23H32O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria[1][2].
IC50 & Target:mineralocorticoid receptor[1]
In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.
Deoxycorticosterone acetate (DOCA) can be used to induce hypertension models[3][4].
Administration: ① 100 mg sustained-release DOCA capsules were implanted subcutaneously and drinking water was replaced with 1% saline; continued for 21 days. ② 15 mg/kg • subcutaneously implanted • drinking water was replaced with 1% saline; twice a week for 2 weeks.
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