Cystamine (dihydrochloride)
CAS No. : 56-17-7
| Size | Price | Stock |
|---|---|---|
| 100g | $23 | In-stock |
| 500g | $88 | In-stock |
| 1000g | $156 | In-stock |
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| Cat. No. : | HY-W020050 |
| M.Wt: | 225.20 |
| Formula: | C4H14Cl2N2S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) [1][2][3].
IC50 & Target:IC50: 23.6 μM (caspase-3)[1]
In Vitro: Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC50 value of 23.6 μM[1].
Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1].
Cystamine (250 μM; 10 h) robustly increases the levels of glutathione[1].
In Vivo: Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice[2].
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