Cetaben
CAS No. : 55986-43-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $180 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $470 | In-stock |
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| Cat. No. : | HY-119964 |
| M.Wt: | 361.56 |
| Formula: | C23H39NO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Cetaben is a PPARα-independent peroxisome proliferator. Cetaben is a non-fibrate hypolipidemic drug and potently reduces the concentration of cholesterol and triglycerides[1][2].
In Vitro: Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles[2].
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells[2].
In Vivo: Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg[1].
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