Polyphyllin VI
CAS No. : 55916-51-3
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| 10mg | $160 | In-stock |
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| Cat. No. : | HY-N0816 |
| M.Wt: | 738.90 |
| Formula: | C39H62O13 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces caspase-1-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer[1][2][3].
In Vitro:Polyphyllin VI (0-16 μM; 48 h) significantly decreases the viability of A549, NCI-H1299 and HepaRG cells in a dose-dependent manner[1][2].
Polyphyllin VI (0.5-2 μM-1 μM; 24 h) significantly increases the percentage of A549, and NCI-H1299 cells in the G2/M stage in a dose-dependent manner[1].
Polyphyllin VI (0-12 μM-1 μM; 24 h) arrests HepaRG cells at S stage [2].
Polyphyllin VI (0-6 μM-1 μM; 24 h) activates the NLRP3 inflammasome[3].
Polyphyllin VI (0-6 μM-1 μM; 24 h) induces pyroptosis via ROS/NF-κB pathway om A549 and NCI-H1299 cells[3].
In Vivo:Polyphyllin VI (2-4 mg/kg; i.p.; five times a week for 4 weeks) inhibits the growth of lung cancer tumor xenografts[1].
Polyphyllin VI (2.5-10 mg/kg; i.p.; 10 consecutive days) activates NLRP3 inflammasome in A549-bearing athymic nude mice[3].
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