Anisodamine
CAS No. : 55869-99-3
(Synonyms: 6-Hydroxyhyoscyamine)
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| Cat. No. : | HY-N0584 |
| M.Wt: | 305.37 |
| Formula: | C17H23NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 20 mg/mL (ultrasonic) |
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[1][2].
IC50 & Target:Nicotinic cholinoceptor[1]
In Vitro: Anisodamine (100 μg/mL; 20 minutes; RAW264.7 cells) pretreatment for 20 minutes before Ach results in significantly attenuates average fluorescence intensity of α-bungarotoxin binding compared with Ach alone[2].
Anisodamine action might be through blockade of muscarinic receptors and thus allowing more endogenous ACh binding to the α-7nAChR[2].
In Vivo: Anisodamine (50 mg/kg; i.p.; 72 hours) markedly decreases the mortality to 20%[2].
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