Clitorin

Clitorin is an orally active flavonoid compound that can be isolated from Carica papaya. Clitorin is an inhibitor of EGFR (IC₅₀: 89.58 nM) and aromatase (IC₅₀: 77.41 nM). Clitorin has antioxidant and anti-tumor activities. In the DPPH and ABTS radical scavenging assays, Clitorin has IC₅₀ values of 91.96 ppm and 250.45 ppm, respectively. In addition, Clitorin can regulate lipogenesis and fatty acid oxidation and can be used in the research of non-alcoholic fatty liver disease^[1][2][3]. In Vitro:Clitorin (24 h) is toxic to MCF-7 breast cancer cells, with an IC₅₀ of 2.47 μM^[1].
Clitorin (50-200 μM; 48 h) can reduce lipid accumulation, decrease the contents of triglycerides and total cholesterol, inhibit the mRNA levels of lipogenic genes, and enhance the mRNA levels of fatty acid oxidation genes in Oleic acid (HY-N1446)-stimulated HepG2 cells^[2]. In Vivo:Clitorin (10-20 mg/kg; oral administration; 4 weeks) has an improving effect in a mouse model of hepatic steatosis^[2].