Azathioprine (sodium)
CAS No. : 55774-33-9
(Synonyms: BW 57-322 (sodium))
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| Cat. No. : | HY-B0256A |
| M.Wt: | 300.25 |
| Formula: | C9H7N7NaO2S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Azathioprine (BW 57-322) sodium is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis[1][3]. In Vitro: Azathioprine (0-50 μM, 48 hours) sodium can induce severe intracellular GSH depletion with relevant concentrations in both primary rat and human hepatocytes[2]. In Vivo: Azathioprine (oral gavage, 25-400 mg/kg, everyday, 10days) sodium can affect bone marrow cells, red blood cells, and peripheral blood cytokines and other related parameters in a dose-dependent manner, and can induce apoptosis in female CD-1 mice and ICR mice[3].
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