Saikogenin D
CAS No. : 5573-16-0
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|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $290 | In-stock |
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| Cat. No. : | HY-N4237 |
| M.Wt: | 472.70 |
| Formula: | C30H48O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2]. In Vitro: Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1]. Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].
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