4-Hydroxyoxyphenbutazone
CAS No. : 55648-39-0
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| Cat. No. : | HY-108050 |
| M.Wt: | 340.37 |
| Formula: | C19H20N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
4-Hydroxyoxyphenbutazone kills both replicating and nonreplicating (NR) Mycobacterium tuberculosis (Mtb), including Mtb resistant to standard drugs. 4-Hydroxyoxyphenbutazone is a potent inhibitor of cytokine production. 4-Hydroxyoxyphenbutazone is an immunosuppressive drug and has the potential for rheumatoid arthritis research[1][2].
In Vitro:4-Hydroxyoxyphenbutazone kills R Mtb in liquid culture with an MIC of 100 μM in the presence of 0.5% BSA and an MIC of 25 μM at lower BSA concentrations. The bactericidal spectrum of 4-Hydroxyoxyphenbutazone is remarkably narrow, with weak activity against Mycobacterium smegmatis (MIC of 200 μM in 7H9 lacking BSA). 4-Hydroxyoxyphenbutazone was inactive on E. coli, S. enterica var[1].
4-Hydroxyoxyphenbutazone efficiently inhibits both monokines and Th1 and Th2 lymphokines in peripheral mononuclear cells (PBMC)[2].
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Inquiry Information- Product Name:
- 4-Hydroxyoxyphenbutazone
- Cat. No.:
- HY-108050
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