Alliin
CAS No. : 556-27-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $56 | In-stock |
| 5mg | $119 | In-stock |
| 10mg | $202 | In-stock |
| 20mg | $343 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $770 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0661 |
| M.Wt: | 177.22 |
| Formula: | C6H11NO3S |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 250 mg/mL (ultrasonic) |
Alliin, an orally active sulfoxide compound that can be isolated from garlic, exhibits hypoglycemic, antioxidant, anti-inflammatory and antitumor activities[1][2].
In Vitro:Alliin (0-160 μM, 2 h) reduces lipid accumulation and ameliorates the cAMP Levels in 1,3-DCP-induced HepG2 cells[1].
Alliin (0-160 μM, 23 h) inhibits the expression levels of proteins and genes (SREBP-1, FAS, SREBP-2 and HMGCR) involved in AMPK–SREBPs signaling pathway in HepG2 Cells[1].
Alliin (100 μM, 6 h) inhibits p38, JNK and ERK1/2 phosphorylation and blocks MAPKs-mediated NF-κB/AP-1/STAT-1 signal transducer to improve the inflammatory responses in LPS-stimulated RAW264.7 cells[2].
In Vivo:Alliin (500 mg/kg, i.g., 10 days) ameliorates colon damage and spleen changes in DSS colitis mouse model through reduces pro-inflammatory cytokines (iNOS, TNF-α and IL-6) expression and inhibits the phosphorylation of ERK1/2, JNK, p38 and PPARγ[2].
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